What Is Calcium Pyruvate?
Pyruvate is a substance that naturally occurs in the body. Pyruvate
(because of pyruvic acid) is the foundation of the Krebs, or Citric Acid,
Cycle. This Cycle, further explained below, is the process (which
uses Pyruvate) through which the body converts glycogen to energy. More
simply, it is how the body burns sugar and starch. Thus, Pyruvate plays a
crucial role in this conversion of food to energy. Pyruvate is the salt
form of pyruvic acid; with Calcium Pyruvate, calcium is
used as the stabilizing mineral. Calcium is the best stabilizing agent for
Pyruvate, as it attracts the least amount of water.
For What Is Calcium
Supplementation of Pyruvate has been shown to increase cellular
respiration, or the amount of energy the mitochondria (the cells'
metabolic furnace) use. The more energy they use, the less excess the body
has to store as fat.
How Should Calcium
Pyruvate Be Used?
There should be an initial "saturation" of 2 pills three times per day
for the first 10 days. Thereafter, the daily amount will decrease to 1
pill 2-3 times daily.
Pyruvate works best when accompanied by exercise--even walking 30 minutes
per day, 3 to 4 days per week can help produce the desired results.
Many Pyruvate users experience an increased appetite resulting from their
increased energy level and metabolism. We suggest Guarana as an appetite
suppressant to offset this increased appetite.
What We Have Experienced
with Calcium Pyruvate
Pyruvate is a great dietary supplement that works best
for moderately active people--20 to 30 minutes of exercise (walking
counts) 3 to 4 times per week. Most people notice an increase in their
energy level after about 10 days.
How Pyruvate Works; The
Krebs Cycle Explained
The following diagram
shows the role of Pyruvate in the Krebs Cycle.
- There are ten steps to the
Krebs Cycle. It takes 2 turns of the Krebs Cycle to metabolize each
- The unstable bond of acetyl
CoA breaks, and the two-carbon acetyl group bonds to the four-carbon
oxaloacetic acid to form six-carbon citric acid.
- Two major events occur during
this step: Isocitric acid loses carbon dioxide leaving a five-carbon
molecule and the five-carbon compound is oxidized, reducing NAD+.
- A multienzyme complex
catalyzes: the removal of carbon dioxide, the oxidation of the remaining
four-carbon compound, reduction of NAD+, and the attachment of CoA with
a high energy bond to form succinyl CoA.
- Substrate level
phosphorylation occurs in a series of enzyme catalyzed reactions: the
high energy bond in succinyl-CoA breaks, and some energy is conserved as
CoA is displaced by a phosphate group. The phosphate group is
transferred to GDP to form GTP and succinic acid. GTP donates a
phosphate group to ADP to form ATP.
- Succinic acid is oxidized to
fumaric acid and FAD is reduced: Two hydrogens are transferred to FAD to
form FADH2 (FADH2 stores less energy than NADH.) The dehydrogenase that
catalyzes this reaction is bound to the inner mitochondrial membrane.
- Water is added to fumaric acid
which rearranges its chemical bonds to form malic acid.
- Malic acid is oxidized and NAD
- A molecule of NADH is
- Oxaloacetic acid is
regenerated to begin the cycle again.
*Note that for every turn of the Krebs Cycle:
- Two carbons enter in the acetyl fragment of Acetyl CoA.
- Two different carbons leave as carbon dioxide.
- Coenzymes are reduced; three NADH and one FADH2 are produced.
- One ATP molecule is produced by substrate level phosphorylation.
- Oxaloacetic acid is regenerated.
- For every glucose molecule split during glycolysis, two acetyl
fragments are produced. Thus, it takes two turns of the cycle to
complete the oxidation of glucose.
- Reduced coenzymes produced by the Krebs Cycle (6 NADH and 2 FADH2
per glucose) carry high energy electrons to the electron transport chain
where ATP is produced by chemiosmosis. Most of the ATP output of
respiration results from this oxidative phosphorylation.
Summary: To put all of this chemistry (which is
admittedly difficult to follow) into laypersons' terms, the faster the
Krebs Cycle turns, the more energy (ATP) a person has, and the more
calories they burn. And, Pyruvate makes the Krebs Cycle run faster.
Weight loss occurs when a person burns more calories than s/he ingests.
Therefore, eating less, eating right, and exercising are essential to your
weight loss program. Easier said than done! Additionally, it is important
to focus on fat loss as opposed to just weight
loss, since nobody has a reason to want to lose lean muscle tissue. The
products we offer can be a valuable aid in your effort, if used
responsibly. Our customers who heed this advice invariable succeed and
often report to us that our products were helpful to them. Remember, it is
impossible to "lose weight overnight" in a healthy manner. Permanent,
healthy weight loss takes time and dedication. Good luck, we know you can